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MS/PhD Biochemist/Biophysicist
Cambridge, MA
Job Description
Job ID
322133BR
MS/PhD Biochemist/Biophysicist
One purpose - to reimagine medicine! The Novartis Oncology Disease Area is seeking a highly motivated, creative, and collaborative scientist to join the Biological Chemistry (BC) group in a hands-on role to discover the next generation of innovative cancer treatments. We are an early stage drug discovery team focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization and optimization of small molecule therapeutics.
The ideal candidate for this position will have a breadth of experience in developing biochemical and biophysical assays, profiling small molecules against protein targets, and collaborating with multidisciplinary project teams. This position will require excellent technical ability at the bench, an eagerness to learn new things, and the willingness to tackle challenging scientific questions.
Your key responsibilities include, but are not limited to:
- Function as a protein biochemistry/biophysics expert within an interdisciplinary team contributing to the execution of experiments in support of the research activities and project goals. The role will quickly evolve as the primary line function representative within a project team.
- Design, develop, and troubleshoot biochemical/biophysical assays using various detection technologies to identify and characterize the mode of binding of small molecule modulators to cancer targets.
- Assess and implement emerging cutting edge technologies and novel assay approaches to advance drug discovery programs
- Opportunity to mentor junior scientists
- Communicate, collaborate and challenge assumptions to push scientific boundaries with a diverse team of cross-functional scientists
Commitment to Diversity & Inclusion:
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Minimum requirements
What you will bring to the role:
Desirable Requirements:
- MS degree or a PhD in Biochemistry, Biophysics, Enzymology or related field with 7+ years (MS) or with 0-3 years (PhD) of relevant small molecule drug discovery experience
- Solid understanding of protein function and enzyme mechanism; experience with biochemical and/or biophysical assay development for protein targets and small molecule inhibitor characterizations as well as protein-ligand binding interactions
- Experience with mass spectrometry-based activity/binding assays is highly desired, in addition to experience with fluorescence-based assay techniques (e.g. HTRF, FP, or quench assays) and label-free technologies (e.g. SPR, ITC, MST, DSF)
- Hands-on experience with automation to enable medium to high throughput assays is a plus
- Proven ability to analyze, interpret and present large datasets in a clear and concise manner
- Excellent team-player, with strong communication and inter-personal skills
- Structural Biology experience a plus.
Why consider Novartis?
769 million. That's how many lives our products touched in 2020. And while we're proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people's lives?
We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you're given opportunities to explore the power of digital and data. Where you're empowered to risk failure by taking smart risks, and where you're surrounded by people who share your determination to tackle the world's toughest medical challenges.
Imagine what you could do at Novartis!
Division
NIBR
Business Unit
Oncology NIBR
Country
USA
Work Location
Cambridge, MA
Company/Legal Entity
NIBRI
Functional Area
Research & Development
Job Type
Full Time
Employment Type
Regular
Shift Work
No
Early Talent
No
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
322133BR
MS/PhD Biochemist/Biophysicist
One purpose - to reimagine medicine! The Novartis Oncology Disease Area is seeking a highly motivated, creative, and collaborative scientist to join the Biological Chemistry (BC) group in a hands-on role to discover the next generation of innovative cancer treatments. We are an early stage drug discovery team focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization and optimization of small molecule therapeutics.
The ideal candidate for this position will have a breadth of experience in developing biochemical and biophysical assays, profiling small molecules against protein targets, and collaborating with multidisciplinary project teams. This position will require excellent technical ability at the bench, an eagerness to learn new things, and the willingness to tackle challenging scientific questions.
Your key responsibilities include, but are not limited to:
- Function as a protein biochemistry/biophysics expert within an interdisciplinary team contributing to the execution of experiments in support of the research activities and project goals. The role will quickly evolve as the primary line function representative within a project team.
- Design, develop, and troubleshoot biochemical/biophysical assays using various detection technologies to identify and characterize the mode of binding of small molecule modulators to cancer targets.
- Assess and implement emerging cutting edge technologies and novel assay approaches to advance drug discovery programs
- Opportunity to mentor junior scientists
- Communicate, collaborate and challenge assumptions to push scientific boundaries with a diverse team of cross-functional scientists
Commitment to Diversity & Inclusion:
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Minimum requirements
What you will bring to the role:
Desirable Requirements:
- MS degree or a PhD in Biochemistry, Biophysics, Enzymology or related field with 7+ years (MS) or with 0-3 years (PhD) of relevant small molecule drug discovery experience
- Solid understanding of protein function and enzyme mechanism; experience with biochemical and/or biophysical assay development for protein targets and small molecule inhibitor characterizations as well as protein-ligand binding interactions
- Experience with mass spectrometry-based activity/binding assays is highly desired, in addition to experience with fluorescence-based assay techniques (e.g. HTRF, FP, or quench assays) and label-free technologies (e.g. SPR, ITC, MST, DSF)
- Hands-on experience with automation to enable medium to high throughput assays is a plus
- Proven ability to analyze, interpret and present large datasets in a clear and concise manner
- Excellent team-player, with strong communication and inter-personal skills
- Structural Biology experience a plus.
Why consider Novartis?
769 million. That's how many lives our products touched in 2020. And while we're proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people's lives?
We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you're given opportunities to explore the power of digital and data. Where you're empowered to risk failure by taking smart risks, and where you're surrounded by people who share your determination to tackle the world's toughest medical challenges.
Imagine what you could do at Novartis!
Division
NIBR
Business Unit
Oncology NIBR
Country
USA
Work Location
Cambridge, MA
Company/Legal Entity
NIBRI
Functional Area
Research & Development
Job Type
Full Time
Employment Type
Regular
Shift Work
No
Early Talent
No
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.
Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Doctorate
Required Experience
0 to 3 years
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